منابع مشابه
How genes evolve
Many new genes evolve through gene duplication followed by rapid evolution. The rate of the evolutionary process was thought to depend on the interrelationships between a protein’s structure and function, and its biological role. Yuri Wolf et al. used a mathematical model to predict the variables that determine the evolutionary rates of change in genes from Drosophila, Aspergillus, and humans. ...
متن کاملDo essential genes evolve slowly?
Approximately two thirds of all knockouts of individual mouse genes give rise to viable fertile mice. These genes have thus been termed 'non-essential' in contrast to 'essential' genes, the knockouts of which result in death or infertility. Although non-essential genes are likely to be under selection that favours sequence conservation [1], it is predicted that they are less subject to such sta...
متن کاملNoncoding Sequences Near Duplicated Genes Evolve Rapidly
Gene expression divergence and chromosomal rearrangements have been put forward as major contributors to phenotypic differences between closely related species. It has also been established that duplicated genes show enhanced rates of positive selection in their amino acid sequences. If functional divergence is largely due to changes in gene expression, it follows that regulatory sequences in d...
متن کاملHighly expressed genes in yeast evolve slowly.
tion of these findings is that proteins expressed in many The dataset used in this article consists of the remtissues interact with a greater number of molecules and nants of the ancient genome duplication including 376 may also have to function under widely changing cellugene pairs organized into 55 gene clusters (Wolfe and lar conditions. Hence, high pleiotropic constraints on Shields 1997). ...
متن کاملMammalian housekeeping genes evolve more slowly than tissue-specific genes.
Do housekeeping genes, which are turned on most of the time in almost every tissue, evolve more slowly than genes that are turned on only at specific developmental times or tissues? Recent large-scale gene expression studies enable us to have a better definition of housekeeping genes and to address the above question in detail. In this study, we examined 1581 human-mouse orthologous gene pairs ...
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ژورنال
عنوان ژورنال: Genome Biology
سال: 2004
ISSN: 1465-6906
DOI: 10.1186/gb-spotlight-20040407-01